Scientific Reports

Table 2 Linear association between serum free hemoglobin level and white matter hyperintensity volume.

From: Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults

	V_WMH		V_PVWMH		V_DWMH
	β (SE)	P	β (SE)	p	β (SE)	p
All
Male
Hb, unadjusted	− 0.23 (0.06)	< 0.001	− 0.25 (0.06)	< 0.001	− 0.04 (0.07)	0.534
Hb, adjusted*	− 0.15 (0.06)	0.013	− 0.18 (0.06)	0.006	− 0.07 (0.08)	0.350
Female
Hb, unadjusted	− 0.09 (0.07)	0.160	− 0.11 (0.07)	0.127	0.03 (0.07)	0.692
Hb, adjusted*	− 0.06 (0.07)	0.355	− 0.08 (0.07)	0.259	0.06 (0.08)	0.483
Subgroup 1^a
Male
Hb, unadjusted	− 0.21 (0.09)	0.017	− 0.26 (0.10)	0.005	0.004 (0.09)	0.964
Hb, adjusted*	− 0.15 (0.09)	0.113	− 0.20 (0.10)	0.044	− 0.11 (0.11)	0.332
Female
Hb, unadjusted	− 0.07 (0.09)	0.420	− 0.09 (0.10)	0.361	0.15 (0.10)	0.147
Hb, adjusted*	− 0.12 (0.09)	0.194	− 0.14 (0.10)	0.136	0.12 (0.10)	0.269
Subgroup 2^b
Male
Hb, unadjusted	− 0.25 (0.06)	< 0.001	− 0.28 (0.06)	< 0.001	− 0.04 (0.07)	0.540
Hb, adjusted*	− 0.16 (0.07)	0.020	− 0.18 (0.07)	0.009	− 0.06 (0.08)	0.473
Female
Hb, unadjusted	− 0.09 (0.07)	0.171	− 0.10 (0.07)	0.137	0.03 (0.07)	0.683
Hb, adjusted*	− 0.07 (0.07)	0.324	− 0.08 (0.07)	0.234	0.05 (0.08)	0.509

Hb hemoglobin, V_WMH volume of total white matter hyperintensity, V_PVWMH volume of periventricular white matter hyperintensity, V_DWMH volume of deep white matter hyperintensity.
*Adjusted for age, hypertension, diabetes, stroke, cumulative illness rating sore, drinking status, smoking status, systolic blood pressure, body mass index, total cholesterol level, high-density lipoprotein cholesterol level, glomerular filtration rate, and cohort; the stroke was not adjusted as a covariate for the analysis of subgroup 2.
^aParticipants without anemia or iron supplementation.
^bParticipants without a history of stroke.
Significance values are given in bold.

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