Correction to: Scientific Reports https://doi.org/10.1038/srep16382, published online 16 November 2015
This Article contains an error in Figure 2. As a result of a mistake in Figure 2A assembly, the Ki67 expression of SGC7901 cells in AZD6244 1 μM, 2 μM and 3 μM of 48 hours treatment were actually the corresponding photos from 24 hours treatment. The correct Figure 2 and accompanying legend appear below.
AZD6244 inhibits proliferation of gastric cancer cells. The proliferation of gastric cancer cell SGC7901 (A) and BGC823 (B) was determined by IHC of Ki67 (magnification: ~ × 400). Compared with vehicle treated SGC7901 cells, inhibition of proliferation was observed in cells treatment with high concentration of AZD6244 (2, 3 and 4 μM) for 24 hours and all given concentration of AZD6244 (1, 2, 3 and 4 μM) for 48 hours (C). Compared with vehicle treated BGC823 cells, proliferation was suppressed by treatment with high concentration of AZD6244 (3 and 4 μM) for 24 hours and all given concentration of AZD6244 for 48 hours (D). Meanwhile, the CCK-8 assay was carried out to evaluation of cell viability. Relatively high concentration of AZD6244 (2, 3 and 4 μM) was able to suppress cell viability of SGC7901 for 24 and 48 hours. Similarly, reduction of cell viability was observed in cells treatment with high concentration of AZD6244 (3 and 4 μM) for 24 and 48 hours. Furthermore, treatment with AZD6244 at the concentration of 2 μM for 48 hours was also able to inhibit cell viability. *p < 0.05 vs. vehicle treated cells for 24 hours; #p < 0.05 vs. vehicle treated cells for 48 hours.
This change does not affect the conclusions of the Article.
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Gao, JH., Wang, CH., Tong, H. et al. Author Correction: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer. Sci Rep 12, 3697 (2022). https://doi.org/10.1038/s41598-022-07805-0
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DOI: https://doi.org/10.1038/s41598-022-07805-0
