Correction to: Scientific Reports https://doi.org/10.1038/s41598-021-90639-z, published online 26 May 2021
The original version of this Article contained errors, where the intraindividual coefficient of variation (iCOV) was calculated incorrectly.
As a result, in the Results section under the subheading ‘NfL concentrations in serum and plasma withstand delayed processing up to 7 days’,
“For all three altered pre-freezing intervals, intraindividual variation (iCOV) was minimal (for samples stored for 7 days at room temperature; serum: 1.2%, plasma: 1.3%) and reproducibility close to perfect (for samples stored for 7 days at room temperature; serum: ICC = 0.99, plasma: ICC = 0.94).”
now reads:
“For all three altered pre-freezing intervals, intraindividual variation (iCOV) was minimal (for samples stored for 7 days at room temperature; serum: 9.0%, plasma: 6.5%) and reproducibility close to perfect (for samples stored for 7 days at room temperature; serum: ICC = 0.99, plasma: ICC = 0.94).”
Additionally, under the subheading ‘Inter‑assay variability’ of the Results section,
“For sNfL, the iSD was 0.6 pg/mL (range 0.5–1.2), the iCOV 0.1% (range 0.0–0.1) and the ICC 1.0 (range 0.99–1.00). For pNFL, the iSD was 1.6 pg/mL (range 0.8–2.7), the iCOV 0.1% (range 0.1–0.2) and the ICC 0.99 (range 0.90–1.00).”
now reads:
“For sNfL, the iSD was 0.6 pg/mL (range 0.5–1.2), the iCOV 4.8% (range 2.0–6.0) and the ICC 1.0 (range 0.99–1.00). For pNFL, the iSD was 1.6 pg/mL (range 0.8–2.7), the iCOV 12.7% (range 6.0–18.0) and the ICC 0.99 (range 0.90–1.00).”
Furthermore, Table 3 contained errors in the “iCOV (%)” columns for “Freezing intervals: 3 days RT”, “Freezing intervals: 3 days 4-8 °C” and “Freezing intervals: 7 days RT”.
The original Table 3 and accompanying legend appear below.
The original Article has been corrected.
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Altmann, P., Ponleitner, M., Rommer, P.S. et al. Author Correction: Seven day pre-analytical stability of serum and plasma neurofilament light chain. Sci Rep 12, 6514 (2022). https://doi.org/10.1038/s41598-022-10916-3
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DOI: https://doi.org/10.1038/s41598-022-10916-3
