Table 3 Unadjusted logistic regression of clinical parameters, serum and urine biomarkers at hospital discharge and for the association of renal outcome (progression to CKD from CA-AKI).

From: Serum myo-inositol oxygenase levels at hospital discharge predict progression to chronic kidney disease in community-acquired acute kidney injury

Parameter

OR (95% CI)

Percent change with respect to 10% change in level of biomarkers*

P value

Age (years)

1.04 (1.01–1.07)

–

0.011

Sex

Male

Female

1.02 (0.42, 2.46)

–

0.969

Diabetes

No

Yes

2.84 (0.45, 17.99)

–

0.268

Hypertension

No

Yes

3.67 (1.14, 11.80)

–

0.029

RRT (no)

yes

3.10 (0.86, 11.14)

–

0.083

qSOFA score (0)

–

 

1

1.62 (0.54, 4.80)

 

0.388

2

2.24 (0.69, 7.32)

 

0.181

Discharge creatinine (mg/dL)

2.69 (1.54, 4.69)

9.8

 < 0.001

Spot uPCR (mg/g)

2.61 (1.61, 4.23)

9.5

 < 0.001

Serum MiOX (pg/mL)

3.58 (1.84, 6.96)

12.8

 < 0.001

Serum YAP (pg/mL)

1.18 (0.70, 1.96)

1.5

0.534

Urine MIOX/creatinine (pg/g)

1.08 (0.67, 1.73)

0.7

0.759

Urine YAP/creatinine (ng/g)

1.11 (0.69, 1.80)

0.9

0.668

Urine KIM-1/creatinine (pg/g)

1.25 (0.80, 1.95)

2.1

0.321

Urine NGAL/creatinine (ng/g)

2.69 (1.56, 4.63)

9.8

 < 0.001

Urine L-FABP/creatinine (ng/g)

0.68 (0.43, 1.06)

− 3.6

0.090

Urine quinolinate/tryptophan (uQ/T)

1.11 (0.69, 1.81)

0.9

0.664

  1. Continuous variables except for age, are standardized log transformed.
  2. uPCR urine protein creatinine ratio, MIOX myo-inositol oxygenase, YAP Yes-associated protein, KIM-1 kidney injury molecule-1. NGAL neutrophil gelatinase-associated lipocalin, L-FABP liver-type fatty acid binding protein.
  3. *Percentage change with respect to 10% change in levels of biomarkers is represented for the standardized log transformed variable computed from odds ratio (OR) by formula; 100 ×(exp(log(OR) × log(1.1)) − 1).
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