Figure 4

Association between COVID-19 outcomes and the most significant variants: rs2285666, rs2048683, and rs879922. Results combined across cohorts using an inverse variance meta-analysis showing Odd ratios (Confidence interval; [95% CI) for (a) rs2285666 (n = 241 COVID-19-positive cases, n = 21,536 COVID-19-negative), (b) rs2048683 (n = 371 COVID-19-positive cases, n = 83,355 COVID-19-negative), and (c) rs879922(n = 20,177 COVID-19-positive cases, n = 653,646 COVID-19-negative). RR, individuals who have genotype reference/reference for all variants included in burden test; RA, individuals who have genotype reference/alternate for at least one variant; AA, individuals who have genotype alternate/alternate for at least one variant; AAF, alternative allele frequency.