Table 3 Joint association of BMI and family history of cancer on the incidence of breast cancer.

From: Interaction between body mass index and family history of cancer on the risk of female breast cancer

Joint effect

No. of cases

CIR (95%CI) (1/100,000 person-years)

HR (95% CI) *

P value

Joint effect of different exposure combinations

BMI < 24 (Underweight and normal weight)

No family history of cancer

61

92.36 (71.86, 118.71)

1 (reference)

 

With family history of cancer

36

141.78 (102.27, 196.56)

1.48 (0.98, 2.34)

0.062

BMI ≥ 24 (Overweight and obesity)

No family history of cancer

56

92.65 (72.07, 121.69)

1.12 (0.78, 1.62)

0.540

With family history of cancer

43

186.54 (138.25, 251.53)

2.06 (1.39, 3.06)

0.000

Interaction on multiplicative scale

  

Estimate (95%CI)

P value

BMI*Family history of cancer

  

1.25 (0.71, 1.65)

0.443

Interaction on additive scale

  

Estimate (95% CI)

P value

RERI

  

0.29 (0.08, 0.51)

0.007

AP

  

0.37 (0.08, 0.66)

0.047

SI

  

0.41 (0.06, 2.83)

0.766

  1. *Adjusted for age (< 60; ≥ 60 years), education (elementary, secondary, tertiary), personal monthly income (< 2000¥, 2000–4000¥, > 4000¥), marriage status(in marriage, not in marriage), smoking (yes, no), drinking (yes, no), daily fruit and vegetable intake (< 300, > 300 g/day), frequency of preserved food per week(at least once, not even once); frequency of fried and smoked food per week(at least once, not even once); frequency of high-fat food per week(at least once, not even once);family history of cancer (yes, no); BMI(< 24 kg/m2, ≥ 24 kg/m2).
Back to article page