Figure 4

Mutation frequency and mutation type in the bortezomib-insensitive and sensitive groups. (a) Box plots depicting differences in mutation frequency between bortezomib-sensitive and bortezomib-insensitive cancer cell lines using the ggstatsplot R package with ggbetweenstats and Welch’s t-test. (b) Waterfall plot depicting the mutation frequency of genes in both sensitivity groups. T-test (P < 0.05) was used to stratify genes with significantly elevated mutation frequencies between the sensitivity groups. The most deleterious mutations are shown if several mutations affected the same gene. (c) Box plots depicting differences in mutation frequency for cancer drivers between bortezomib-sensitive and bortezomib-insensitive cancer cell lines using Welch’s t-test.