Table 2 Different methods of MR of the associations between unhealthy lifestyle factors and colorectal cancer.

From: Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study

Exposure

IVW (fixed effects)

IVW (multiplicative random effects)

MR-Egger

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Smoking

 AgeSmk

3.48 (1.15, 10.55)

0.028

3.48 (1.11, 10.85)

0.032

1.58 (0.01, 229.87)

0.869

 CigDay

1.30 (1.01, 1.68)

0.042

1.30 (1.04, 1.62)

0.019

1.16 (0.75, 1.79)

0.518

 SmkInit

0.86 (0.74, 1.00)

0.055

0.86 (0.73, 1.02)

0.078

0.70 (0.36, 1.37)

0.303

 SmkCes

1.02 (0.70, 1.48)

0.929

1.02 (0.73, 1.41)

0.918

0.92 (0.31, 2.75)

0.888

Alcohol consumption

 DrnkWk

0.75 (0.49, 1.17)

0.209

0.75 (0.44, 1.30)

0.306

1.46 (0.40, 5.32)

0.572

Obesity

 BMI

1.12 (0.98, 1.29)

0.100

1.12 (0.97, 1.30)

0.124

1.19 (0.83, 1.69)

0.342

 WHR

1.38 (1.16, 1.64)

0.000

1.38 (1.12, 1.70)

0.002

1.35 (0.80, 2.26)

0.264

Physical activity

 AccAve

0.97 (0.90, 1.05)

0.468

0.97 (0.87, 1.09)

0.616

1.20 (0.77, 1.87)

0.461

 MVPA

0.59 (0.31, 1.11)

0.104

0.59 (0.29, 1.19)

0.140

0.12 (0.00, 6.47)

0.310

 VPA

0.36 (0.08, 1.71)

0.199

0.36 (0.09, 1.37)

0.135

0.55 (0.00, 95,849.97)

0.927

 SSOE

1.84 (0.41, 8.24)

0.427

1.84 (0.51, 6.57)

0.349

0.05 (0.00, 66.90)

0.439

  1. AgeSmk age of initiation of regular smoking, SmkInit a binary phenotype indicating whether an individual had ever smoked regularly, CigDay heaviness of smoking was measured with cigarettes per day, SmkCes smoking cessation, DrnkWk available measures of alcohol use were simpler, with drinks per week, AccAve accelerometer-based physical activity measurement (average acceleration), MVPA moderate-to-vigorous physical activity, SSOE strenuous sports or other exercise, VPA vigorous physical activity.
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