Table 3 Different methods of MR of the associations between unhealthy lifestyle factors and colorectal cancer.

From: Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study

Exposure

Weighted median method

MR-PRESSO

MR-PRESSO adjusted

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Smoking

 AgeSmk

3.46 (0.79,15.21)

0.101

3.48 (1.11,10.85)

0.098

  

 CigDay

1.17 (0.82,1.66)

0.398

1.30 (1.04,1.62)

0.025

  

 SmkInit

0.86 (0.69,1.09)

0.208

0.86 (0.73,1.02)

0.080

  

 SmkCes

0.85 (0.51,1.42)

0.530

1.02 (0.73,1.41)

0.921

  

Alcohol consumption

 DrnkWk

1.01 (0.47,2.15)

0.981

0.75 (0.44,1.30)

0.310

0.83 (0.50,1.37)

0.464

Obesity

 BMI

1.12 (0.87,1.45)

0.373

1.12 (0.97,1.30)

0.125

  

 WHR

1.47 (1.09,2.00)

0.012

1.38 (1.12,1.70)

0.003

1.35 (1.12,1.63)

0.002

Physical activity

 AccAve

0.96 (0.86,1.07)

0.450

0.97 (0.87,1.09)

0.637

  

 MVPA

0.43 (0.18,1.04)

0.061

0.59 (0.29,1.19)

0.158

  

 VPA

0.19 (0.03,1.38)

0.101

0.36 (0.09,1.37)

0.185

  

 SSOE

1.06 (0.13,8.90)

0.955

1.84 (0.51,6.57)

0.369

  
  1. AgeSmk age of initiation of regular smoking, SmkInit a binary phenotype indicating whether an individual had ever smoked regularly, CigDay heaviness of smoking was measured with cigarettes per day, SmkCes smoking cessation, DrnkWk available measures of alcohol use were simpler, with drinks per week, AccAve accelerometer-based physical activity measurement (average acceleration), MVPA moderate-to-vigorous physical activity, SSOE strenuous sports or other exercise, VPA vigorous physical activity.
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