Table 4 Sensitivity test of MR of the associations between unhealthy lifestyle factors and colorectal cancer.

From: Unhealthy lifestyle factors and the risk of colorectal cancer: a Mendelian randomization study

Exposure

MR-Egger regression analysis

Cochran’s Q test

Intercept

P-value

Q statistic

P-value

Smoking

 AgeSmk

0.015

0.769

4.21

0.379

 CigDay

0.004

0.518

24.82

0.846

 SmkInit

0.004

0.543

200.82

0.048

 SmkCes

0.004

0.856

6.810

0.008

Alcohol consumption

 DrnkWk

− 0.009

0.278

87.34

0.310

 BMI

− 0.001

0.733

308.89

0.052

 WHR

0.000

0.916

245.24

0.000

Physical activity

 AccAve

− 0.060

0.386

10.45

0.064

 MVPA

0.024

0.433

20.62

0.244

 VPA

− 0.004

0.947

4.43

0.619

 SSOE

0.029

0.343

7.92

0.720

  1. AgeSmk age of initiation of regular smoking, CigDay heaviness of smoking was measured with cigarettes per day, SmkInit a binary phenotype indicating whether an individual had ever smoked regularly, SmkCes smoking cessation, DrnkWk available measures of alcohol use were simpler, with drinks per week, AccAve accelerometer-based physical activity measurement (average acceleration), MVPA moderate-to-vigorous physical activity, SSOE strenuous sports or other exercise, VPA vigorous physical activity.
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