Table 6 Effect size of TG/HDL-c ratio on TA in prespecified and exploratory subgroups.

From: Inverse relationship between LDL-C/HDL-C ratio and atrial fibrillation in chronic kidney disease patients

Characteristic

No of participants

HR (95%CI)

P-value

P for interacion

Gender

   

0.4731

 Male

16,857

0.45 (0.28, 0.73)

0.0012

 

 Female

4234

0.30 (0.10, 0.87)

0.0276

 

eGFR (mL/min/1.73 m2)

   

0.4580

  ≥ 60

9510

0.36 (0.20, 0.66)

0.0009

 

  < 60

11,581

0.50 (0.27, 0.94)

0.0325

 

Age (years)

   

0.8295

  < 64

13,658

0.39 (0.17, 0.92)

0.0312

 

  ≥ 64, < 75

5093

0.47 (0.25, 0.89)

0.0211

 

  ≥ 75

2340

0.34 (0.15, 0.79)

0.0124

 

Waist

   

0.6978

 Normal

13,062

0.47 (0.25, 0.87)

0.0159

 

 Overweight

8029

0.40 (0.21, 0.73)

0.0031

 

Proteinuria

   

0.0607

 No

10,011

0.73 (0.37, 1.45)

0.3691

 

 Yes

11,080

0.31 (0.18, 0.54)

 < 0.0001

 

Education

   

0.9429

  ≤ 9 years

18,217

0.43 (0.27, 0.69)

0.0004

 

  > 9 years

2874

0.41 (0.11, 1.50)

0.1791

 

Smoke

   

0.4043

 No

13,417

0.47 (0.29, 0.78)

0.0034

 

 Yes

7674

0.31 (0.13, 0.74)

0.0083

 

Alcohol intake

   

0.6897

 No

14,183

0.44 (0.27, 0.73)

0.0015

 

 Yes

6908

0.36 (0.15, 0.87)

0.0232

 

Hypertension

   

0.0016

 No

16,168

0.26 (0.15, 0.45)

 < 0.0001

 

 Yes

4923

1.09 (0.54, 2.17)

0.8131

 

DM

   

0.4732

 No

19,215

0.41 (0.26, 0.65)

0.0002

 

 Yes

1876

0.67 (0.19, 2.32)

0.5275

 
  1. Note 1: Above model adjusted for age, gender, WC, education, history of alcohol intake, smoking, DM, hypertension, MI, PAD, DBP, SBP, CRP, proteinuria, TG, eGFR.
  2. Note 2: In each case, the model is not adjusted for the stratification variable.
  3. HR hazard ratios; CI confidence; Ref reference.
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