Figure 3 | Scientific Reports

Figure 3

From: Short-chain fatty acids ameliorate imiquimod-induced skin thickening and IL-17 levels and alter gut microbiota in mice: a metagenomic association analysis

Figure 3Figure 3

SCFA supplements and IL-17 antagonists enhanced the richness and diversity of fecal microbiota. We compared the α-diversities of fecal microbiota between (A) IMQ mice receiving isotype injections plus SCFA supplements and not receiving SCFA supplements and (B) IMQ mice receiving anti-IL17 or IgG isotype treatment. There were significant differences in the β-diversity of fecal microbiota between IMQ mice receiving (C) IgG isotypes with or without SCFA supplements, but not between (D) IMQ mice with anti-IL17 and IMQ mice with IgG isotype treatment. Between-group inertia percentages were tested using the Monte-Carlo test (with 10,000 permutations) with Bray–Curtis method. p values less than 0.05 were considered significant. The organismal features differentiating communities of fecal microbiota between experimental and control mice were presented by LEfSe, applied with α of 0.05 (Kruskal–Wallis and Wilcoxon tests), as described in the “Methods” section.

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