Figure 4 | Scientific Reports

Figure 4

From: Short-chain fatty acids ameliorate imiquimod-induced skin thickening and IL-17 levels and alter gut microbiota in mice: a metagenomic association analysis

Figure 4

The discriminating microbial species and discriminating metabolic pathways of IMQ mice receiving: (A) SCFAs, (B) anti-IL17, or (C) combination SCFAs and anti-IL17 treatment. The discriminating metabolic pathways in IMQ mice enhanced by (D) SCFA supplements or (E) anti-IL17 treatment and (F) the top 20 discriminating genes after SCFAs. The abundances of various gene families between experiments were scaled by total sum per sample and subjected to enrichment analysis of two-group comparison using several tests, including Wilcoxon signed rank test, ANOVA rank test, or Kruskal–Wallis test with a Benjamin-Hochberg false discovery rate (FDR) correction to adjust p values for multiple testing.

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