Table 3 Prognostic factors associated breast cancer-specific survival using Cox proportional hazards analysis for patients with cT1 triple-negative breast cancer.
From: Evaluation of neoadjuvant chemotherapy for clinical T1 triple-negative breast cancer
Characteristics | Total | HR (univariable) | P value | HR (multivariable) | P value |
|---|---|---|---|---|---|
Group | |||||
AC | 5404 (86.5%) | Reference | Reference | ||
NAC | 845 (13.5%) | 2.26 (1.86–2.75) | < 0.001 | 1.54 (1.26–1.89) | < 0.001 |
Age | |||||
< 50 | 1818 (29.1%) | Reference | Reference | ||
≥ 50 | 4431 (70.9%) | 0.87 (0.72–1.04) | 0.114 | 1.02 (0.85–1.23) | 0.835 |
Race | |||||
White | 4663 (74.6%) | Reference | Reference | ||
Black | 1103 (17.7%) | 1.35 (1.11–1.65) | 0.003 | 1.30 (1.05–1.59) | 0.014 |
Other | 483 (7.7%) | 0.71 (0.49–1.04) | 0.075 | 0.71 (0.49–1.04) | 0.081 |
Marital status | |||||
Married | 4063 (65.0%) | Reference | Reference | ||
Not married | 2186 (35.0%) | 1.17 (0.98–1.39) | 0.078 | 1.11 (0.93–1.33) | 0.228 |
Histology | |||||
Ductal | 5613 (89.8%) | Reference | Reference | ||
Ductal/lobular | 58 (0.9%) | 2.03 (1.08–3.79) | 0.027 | 1.66 (0.88–3.12) | 0.115 |
Lobular | 34 (0.5%) | 1.01 (0.32–3.13) | 0.991 | 0.91 (0.29–2.87) | 0.878 |
Other | 544 (8.7%) | 0.61 (0.42–0.88) | 0.009 | 0.59 (0.41–0.85) | 0.005 |
Grade | |||||
I | 89 (1.4%) | Reference | Reference | ||
II | 1133 (18.1%) | 4.06 (1.00–16.44) | 0.05 | 3.13 (0.77–12.70) | 0.111 |
III | 4990 (79.9%) | 4.13 (1.03–16.56) | 0.45 | 2.98 (0.74–11.99) | 0.124 |
IV | 37 (0.6%) | 6.42 (1.25–33.08) | 0.26 | 4.53 (0.88–23.43) | 0.071 |
T stage | |||||
T1a | 233 (3.7%) | Reference | Reference | ||
T1b | 1332 (21.3%) | 1.15 (0.63–2.12) | 0.647 | 1.34 (0.73–2.46) | 0.349 |
T1c | 4684 (75.0%) | 1.98 (1.12–3.51) | 0.019 | 1.93 (1.09–3.43) | 0.025 |
N stage | |||||
N0 | 4869 (77.9%) | Reference | Reference | ||
N1 | 1380 (17.5%) | 2.91 (2.41–3.53) | < 0.001 | 2.57 (2.11–3.13) | < 0.001 |
N2–N3 | 284 (4.5%) | 7.82 (6.23–9.81) | < 0.001 | 6.40 (5.01–8.18) | < 0.001 |
Surgery | |||||
BCS | 4099 (65.6%) | Reference | Reference | ||
Mastectomy | 2150 (34.4%) | 1.58 (1.34–1.87) | < 0.001 | 1.34 (1.10–1.64) | 0.004 |
Radiotherapy | |||||
None/unknown | 2623 (42.0%) | Reference | Reference | ||
Yes | 3626 (58.0%) | 1.09 (0.91–1.29) | 0.346 | 1.15 (0.94–1.40) | 0.164 |
