Figure 1

Measurement of CT-based bone density by manually placed ROI. CT-based bone density was measured by first locating the Th12 vertebral body in the sagittal plane (A). Subsequently, in the axial plane, a circular region of interest (ROI) was placed stretching from the anterior aspect of the vertebral body to the anterior side of the basivertebral vein (B). The mean CT-based bone density within the ROI was determined using the IDS7 software.