Table 2 Changes in mRNA expression from culturing monocytes on soft, anti-fibrotic (1 kPa) and stiff, pro-fibrotic (12 kPa) surfaces, assessed by RNAseq.

From: Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis

mRNA sequences

Fold change

ITGAM

1.797671

ITGA3

3.536679

ITGA7

4.487744

  1. These mRNA sequences were downregulated by monocyte culture on 1 kPa surfaces, compared to 12 kPa surfaces. These were among the protein targets investigated as possible modulators of myofibroblast differentiation.
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