Table 4 Diagnostic efficacy parameter of 4 diagnostic models.
miRNAs | AUC | 95% CI | P-value | cutoff | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|---|---|
(A) Model 1 | ||||||||
miR-21 | 0.762 | 0.658–0.846 | < 0.001 | > 1.032 | 84.5 | 69.0 | 84.5 | 68.9 |
miR-29c | 0.795 | 0.694–0.874 | < 0.001 | > 1.605 | 98.3 | 67.9 | 86.3 | 95.0 |
Combination | 0.802 | 0.702–0.880 | < 0.001 | > 0.430 | 96.5 | 62.1 | 83.4 | 90.0 |
(B) Model 2 | ||||||||
miR-21 | 0.762 | 0.658–0.846 | < 0.001 | > 1.032 | 84.5 | 69.0 | 84.5 | 68.9 |
miR-29c | 0.795 | 0.694–0.874 | < 0.001 | > 1.605 | 98.3 | 67.9 | 86.3 | 95.0 |
miR-205 | 0.691 | 0.582–0.787 | 0.001 | > 2.642 | 41.1 | 89.7 | 88.5 | 44.1 |
Combination | 0.810 | 0.711–0.887 | < 0.001 | > 0.377 | 98.2 | 48.3 | 78.6 | 93.3 |
(C) Model 3 | ||||||||
miR-19a | 0.687 | 0.579–0.782 | 0.003 | ≤ 0.919 | 82.8 | 55.2 | 78.7 | 61.6 |
miR-21 | 0.762 | 0.658–0.846 | < 0.001 | > 1.032 | 84.5 | 69.0 | 84.5 | 68.9 |
miR-29c | 0.795 | 0.694–0.874 | < 0.001 | > 1.605 | 98.3 | 67.9 | 86.3 | 95.0 |
miR-205 | 0.691 | 0.582–0.787 | 0.001 | > 2.642 | 41.1 | 89.7 | 88.5 | 44.1 |
Combination | 0.837 | 0.742–0.908 | p < 0.001 | > 0.582 | 87.5 | 72.4 | 86.0 | 75.0 |
