Fig. 8 | Scientific Reports

Fig. 8

From: Downregulation of CIAPIN1 regulates the proliferation, migration and glycolysis of breast cancer cells via inhibition of STAT3 pathway

Fig. 8

Inhibition of CIAPIN1 suppresses glycolysis in breast cancer cells through STAT3/PKM2 pathway. The energy metabolism by inhibition of CIAPIN1 was measured in the lysate of MDA-MB-231 and MDA-MB-453 cells on (A) pyruvate, (B) lactate and (C) ATP. (D) Representative gel blots depicting levels of PKM2 (normalized to GAPDH) and phosphorylated STAT3 (p-STAT3, normalized to total STAT3). Quantification analysis shows that Inhibition of CIAPIN1 reduced the PKM2 protein expression and phosphorylation of STAT3 (E, F). Data represent the average of three independent experiments (mean ± SD). ***P < 0.001 vs. si-NC group.

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