Fig. 7
Effect of inhibition of IL-1 on chondrocyte gene expression and associated pathways in osteochondral injury models with synovial co-culture. (a) Relative gene expression for all experimental groups in the presence of IL-1RA compared to the same group without IL-1RA. Data (n = 3 per group) presented as fold change (FC) with statistical analysis performed using two-way ANOVA with Bonferroni’s correction for multiple comparisons (adjusted p-values reported). Genes highlighted in orange are significantly upregulated, and genes highlighted in blue are significantly downregulated. Significant p-values shown in red. (b) Ingenuity pathway Analysis activation z-scores with B–H corrected p-values for top canonical pathways differentially altered with IL-1RA by injury mode (no injury, compression, fracture) and co-culture with synovial cells (no cells, low synovitis, high synovitis).
