Fig. 3
From: Dipeptide metabolite, glutamyl-glutamate mediates microbe-host interaction to boost spermatogenesis
L. plantarum SNI3 affects colon microbiome. (A) Abundance of main phyla and top 20 taxa at genus level in the colon microbiome. Mean ± SEM values **** p < 0.0001 vs. control group. (B) Correlation between the abundance of different microbial populations in the colon and sperm count. Scatter plots showing the relationship between microbial population abundance and sperm number. Each point represents one individual sample (n = 14). (C) Impact of fecal material transplantation (FMT) from L.plantarum SNI3 treated mice on total bacterial DNA concentration in colon content, sperm count and serum testosterone level. No FMT: mice received antibiotic treatment and no FMT (n = 5), Control FMT: mice received antibiotic treatment and fecal microbiome from control, untreated animals (n = 6), SNI3 FMT: mice received antibiotic treatment and fecal microbiome from L. plantarum SNI3 treated mice (n = 13). All microbiome data from two independent cohorts, # FMT data were analyzed by one-way ANOVA followed by Dunnett’s multiple comparison test (n = 6–13 per group). Mean ± SEM values *p < 0.05, **p < 0.01.
