Fig. 6
From: Dipeptide metabolite, glutamyl-glutamate mediates microbe-host interaction to boost spermatogenesis
Identification of differential metabolites and pathways in control vs.L. plantarum SNI3-treated testes. (A) The volcano plot is a combination of fold change (FC) and t-tests. The x-axis is log (FC). Y-axis is log10 (p value) based on FDR adjusted p values. The discriminative metabolites were selected by a volcano plot with fold change > 2 or < 0.5 and p-value < 0.05. (B) Pathway enrichment analyses were performed by KEGG pathway analysis. Discriminative pathways are summarized here. (C) In situ mass spectrometry (MSI) images of select discriminative metabolites. On the left, MSI image of phosphatidylcholine , which is reduced upon L. plantarum SNI3 treatment; on the right, MSI image of glutamyl-glutamate, GluGlu, which is enhanced upon L. plantarum SNI3 treatment in the testis. Unpaired t-test was used for statistical analysis (*: p ≤ 0.05; ***: p ≤ 0.001).
