Fig. 1 | Scientific Reports

Fig. 1

From: Implications of ITCH-mediated ubiquitination of SIX1 on CDC27-cyclinB1 signaling in nasopharyngeal carcinoma

Fig. 1

SIX1 protein expression was increased in NPC tissues and correlated with poor prognosis. (A) The GSE64634 and GSE12452 were analyzed for PCA. (B) Volcano diagram showed the DEGs between tumor(n = 43) and normal samples(n = 14). (C) Heat map showed clustering of differentially expressed genes in tumor and normal samples. (D) The GSE13597 were analyzed for PCA. (E) Volcano diagram showed the DEGs between tumor (n = 25) and normal samples (n = 3). (F) GEPIA2 analysis of the relationship of SIX1 expression on OS (The 208 patients with low SIX1 expression and 285 patients with high SIX1 expression). (G) The result of qPCR confirmed the SIX1 expression in NPC cell lines. (H,I) The SIX1 protein expression level in NP69 and NPC cell lines. The statistical analysis of band grey values was displayed on the side. The data are presented as the mean ± SD values. *P < 0.05; **P < 0.01; ***P<0.001.

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