Table 3 The anti-parasitic activity of X. conspersa hexane and methanolic extract

From: Evaluating the impact of Xanthoparmelia conspersa extracts on signaling in HeLa cells and exploring their diverse biological activities

The primary assay (% of inhibition)

Tested vector

Methanolic extract

(20 µg/mL)

Hexane extract

(20 µg/mL)

Amphotericin B

(1 µg/mL)

Pentamidine

(5 µg/mL)

L. donovani – promastigotes

3

0

98

NT

L. donovani – amastigotes

9

94

96

NT

L. donovani – amastigotes + THP1

10

99

81

NT

THP1

7

92

6

NT

Trypanosoma brucei

2

100

NT

100

The secondary assay (IC50 value, µg/mL)

Tested vector

 

Hexane extract

(20–0,8)*

Amphotericin B

(2.0–0.08)

Pentamidine

(10.0–0.4)

L. donovani-promastigotes

 

ND

0.166 ± 0.05

1.355 ± 0.23

L. donovani – amastigotes

 

2.64 ± 1.04

0.238 ± 0.09

2.008 ± 0.37

L. donovani – amastigotes + THP1

 

6.17 ± 1.34

0.188 ± 0.07

6.951 ± 0.25

THP1

 

1.99 ± 1.00

ND

ND

Tested vector

 

Hexane extract

(20–0,8)*

Pentamidine

(0.02–0.0008)

DFMO

(20–0,8)

Trypanosoma brucei

 

7.18 ± 1.22

0.008 ± 0.001

5.351 ± 1.011

  1. IC50 – 50% (half-maximum) inhibitory concentration (mean ± SD; µg/mL); NT not tested, ND not determined;
  2. DFMO - α-difluoromenthylornithine.
  3. * Test concentration (µg/mL).
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