Fig. 7
METTL3-NEK2 axis regulates the Wnt/β-catenin signaling and apoptosis pathway. (A) qRT-PCR indicated the Wnt1, β-catenin, Bcl2, and Bax mRNA expression in the transfection of NEK2 overexpression or NEK2 knockdown (B) Western blot indicated the Wnt1, β-catenin, Bcl2, and Bax protein expression in the transfection of NEK2 overexpression or NEK2 knockdown. (C) Western blot indicated the Wnt1, and Bcl2 protein expression in the transfection of METTL3 overexpression or METTL3 knockdown. (D) qRT-PCR and Western blot indicated the Wnt1 and β-catenin expression in the transfection of Wnt1 knockdown, Wnt1 knockdown combined with overexpression of NEK2 or METTL3. *P < 0.05. **P < 0.01. ***P < 0.001.
