Fig. 5

IRS acted as an indicator for predicting the immunotherapy response in STAD. The TMB score (A), PD1&CTLA4 immunophenoscore (B), TIDE score (C) in STAD patients with different IRS score. The level of HLA-related genes (D) and immune checkpoints (E) in different IRS score group. The immunotherapy response and overall rate in patients with high and low IRS score in IMvigor210 (F), GSE91061 (G) and GSE78220 (H) datasets. *p < 0.05, **p < 0.01, ***p < 0.001.