Fig. 8
From: Loss of Stim2 in zebrafish induces glaucoma-like phenotype
Pleiotrophic effect of stim2 knockout resembling glaucoma like phenotype in zebrafish. Loss of Stim2 leads to impairment of GABAergic connections, resulting in loss of ganglion cells, causing changes in light perception. Increase in microglia number and their activation36, glycogen deficiency36 as well as mitochondria alterations may be a consequence of the insulin downregulation seen in stim2 KO. GCL, Ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; PL, photoreceptor layer.
