Table 3 Cox proportional hazard ratios (HR). Model 1 was unadjusted. Model 2 was adjusted for gender, age, race, BMI. Model 3 was adjusted for the variables in model 2 and further adjusted for Marital status, ALT, CK, CKMB, SCR, GLU, HB, HBA1C, Neutrophil, Platelet, TC, WBC, AF, Alcohol use, Anemia, Cancer, CHD, CKD, DM, HF, HBP, HL, RF, Tobacco use, Anticoagulant drugs, Antiplatelet drugs, APSIII, SAPS II. aACAG Quartile: Q1:<15.300; Q2: 15.300–17.850; Q3: 17.850–20.175; Q4: >20.175. HR(Hazard Ratio), CI (Confidence Interval).

From: Association of albumin-corrected anion gap with severe consciousness disorders and outcomes in ischemic stroke: a retrospective MIMIC analysis

Outcomes

Model 1

Model 2

Model 3

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

GCS < = 8

      

ACAG

1.055(1.035, 1.077)

< 0.001

1.049(1.027, 1.071)

< 0.001

1.032(1.012, 1.053)

0.002

ACAG Quartilea

p for trend < 0.001

 

p for trend = 0.004

 

p for trend = 0.048

 

Q1, N = 601

Ref

 

Ref

 

Ref

 

Q2, N = 605

1.07(0.775, 1.478)

0.7

0.87(0.564, 1.341)

0.002

1.046(0.819, 1.337)

0.7

Q3, N = 578

1.015(0.734, 1.403)

> 0.9

1.257(0.843, 1.875)

< 0.001

0.958(0.749, 1.226)

0.7

Q4, N = 595

1.782(1.339, 2.372)

< 0.001

1.825(1.273, 2.618)

< 0.001

1.382(1.129, 1.692)

0.002

In-hospital mortality

      

ACAG

1.047(1.026, 1.069)

< 0.001

1.05(1.026, 1.074)

< 0.001

1.03(0.997, 1.064)

0.071

ACAG Quartilea

p for trend < 0.001

 

p for trend = 0.004

 

p for trend = 0.042

 

Q1, N = 601

Ref

 

Ref

 

Ref

 

Q2, N = 605

0.87(0.564, 1.341)

0.5

0.834(0.541, 1.288)

0.4

0.924(0.591, 1.445)

0.7

Q3, N = 578

1.257(0.843, 1.875)

0.3

1.131(0.756, 1.691)

0.6

1.291(0.836, 1.996)

0.2

Q4, N = 595

1.825(1.273, 2.618)

0.001

1.603(1.114, 2.308)

0.011

1.437(0.940, 2.197)

0.094

long-term mortality

      

ACAG

1.082(1.070, 1.096)

< 0.001

1.094(1.080, 1.109)

< 0.001

1.065(1.044, 1.087)

< 0.001

ACAG Quartilea

p for trend < 0.001

 

p for trend < 0.001

 

p for trend < 0.001

 

Q1, N = 601

Ref

 

Ref

 

Ref

 

Q2, N = 605

1.423(1.144, 1.770)

0.002

1.474(1.182, 1.839)

< 0.001

1.451(1.156, 1.821)

0.001

Q3, N = 578

2.101(1.697, 2.602)

< 0.001

2.07(1.663, 2.575)

< 0.001

1.967(1.555, 2.489)

< 0.001

Q4, N = 595

3.184(2.603, 3.896)

< 0.001

3.295(2.676, 4.058)

< 0.001

2.087(1.637, 2.660)

< 0.001

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