Table 4 Predictive performance of ultra-early DW-MRI for poor neurological outcomes based on ROSC to DW-MRI scan-interval.

From: Optimal timing of ultra-early diffusion-weighted MRI in out-of-hospital cardiac arrest patients based on a retrospective multicenter cohort study

ROSC to DW-MRI scan-interval, n

Sensitivity (95%CI)

Specificity (95%CI)

PPV (95%CI)

NPV (95%CI)

TP

FP

TN

FN

P-value

Overall patients

 Enrolled patients, 206*

82 (74–88)

100 (95–100)

100 (97–100)

76 (66–84)

108

0

74

24

< 0.001

 < 2.2 h, 78*

70 (54–83)

100 (90–100)

100 (88–100)

73 (58–85)

30

0

35

13

< 0.001

 ≥ 2.2 h, 128*

88 (79–94)

100 (91–100)

100 (95–100)

78 (64–89)

78

0

39

11

< 0.001

Low-flow time

Less than or equal to 21 min

 Enrolled patients, 89*

54 (34–73)

100 (94–100)

100 (78–100)

82 (72–90)

15

0

61

13

< 0.001

 < 2.2 h, 39*

27 (6–61)

100 (88–100)

100 (29–100)

78 (61–90)

3

0

28

8

0.21

 ≥ 2.2 h, 50*

71 (44–90)

100 (89–100)

100 (74–100)

87 (72–96)

12

0

33

5

< 0.001

Greater than 21 min

 Enrolled patients, 117*

89 (82–95)

100 (75–100)

100 (96–100)

54 (33–74)

93

0

13

11

< 0.001

 < 2.2 h, 39*

84 (67–95)

100 (59–100)

100 (87–100)

58 (28–85)

27

0

7

5

< 0.001

 ≥ 2.2 h, 78*

92 (83–97)

100 (54–100)

100 (95–100)

50 (21–79)

66

0

6

6

< 0.001

First monitored rhythm

Shockable rhythm

 Enrolled patients, 58*

75 (48–93)

100 (92–100)

100 (74–100)

72 (59–83)

12

0

42

4

< 0.001

 < 2.2 h, 27*

67 (9–99)

100 (86–100)

100 (16–100)

96 (80–100)

2

0

24

1

0.06

 ≥ 2.2 h, 31*

77 (46–95)

100 (82–100)

100 (69–100)

86 (64–97)

10

0

18

3

< 0.001

Non-shockable rhythm

 Enrolled patients, 148*

83 (75–89)

100 (89–100)

100 (96–100)

62 (47–75)

96

0

32

20

< 0.001

 < 2.2 h, 51*

71 (54–83)

100 (72–100)

100 (88–100)

48 (27–69)

28

0

11

12

< 0.001

 ≥ 2.2 h, 97*

89 (80–95)

100 (84–100)

100 (95–100)

72 (53–87)

68

0

21

8

< 0.001

  1. DW-MRI, diffusion-weighted magnetic resonance imaging; ROSC, return of spontaneous circulation; CI, confidence interval; PPV, positive-predictive value; NPV, negative-predictive value; TP, true-positive; FP, false-positive; TN, true-negative; FN, false-negative.
  2. *Number of patients included in the analysis.