Fig. 3 | Scientific Reports

Fig. 3

From: ST2L promotes VEGFA-mediated angiogenesis in gastric cancer by activating TRAF6/PI3K/Akt/NF-κB pathway via IL-33

Fig. 3

ST2L induces gastric cancer angiogenesis in vitro by binding to its ligand IL-33, and this effect can be blocked by sST2. (A) The protein-protein interactions of IL1RL1-associated proteins. (B) Correlation analysis of IL1RL1 and IL-33 expression in STAD patients based on the data from TCGA database. (C) Kaplan-Meier analysis of OS related to the IL-33 expression in STAD patients according to the data from TCGA database. The effect of the corresponding CM on the migration (D, F, H) and the vascular formation (E, G, I) of HUVECs. (J, K) Western blot analysis of VEGFA protein expression level. (L, M) The concentration of VEGFA in the cell supernatant of each group was detected by ELISA. *P < 0.05, **P < 0.01, ***P < 0.001. Original blots/gels are presented in Supplementary Figure. The samples were derived from the same experiment and the gels/blots were processed in parallel.

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