Fig. 1
Scoring System and Integrated Approach for identification of cancer driver genes in HGSOC. Weighted scoring system by incorporating 8 different parameters to score and rank the (a) amplified and (b) deleted genes. Genes fulfilling all criteria received a maximum score of 24. (c) Framework for identification of driver genes. Focal SCNA data for the TCGA HGSOC dataset were downloaded from the Broad Institute FIREHOSE portal. Genes were shortlisted based on the significance of alteration pā<ā0.05 and scoreāā„ā5 (d) Oncoprint showing alterations of RNF144B in TCGA HGSOC dataset e Oncoprint of PPP2R2A alterations in TCGA HGSOC dataset.
