Table 4 Association of FTO variants with biochemical marker and hormone parameters according to dominant and non-dominant with non-obese and obese group.
Variables | FTO rs9939609 | FTO rs1421085 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TT (n = 226) | p value | TA + AA (n = 158) | p value | p value | TT (n = 221) | p value | TC + CC (n = 163) | p value | p value | |||||||
Non-Obese | Obese | Non-Obese | Obese | Between Genotype | Non-Obese | Obese | Non-Obese | Obese | Between Genotype | |||||||
(n = 115) | (n = 111) | (n = 70) | (n = 88) | (TT and TA + AA) | (n = 114) | (n = 107) | (n = 71) | (n = 92) | (TT and TC + CC) | |||||||
Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Non-obese | Obese | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Non-obese | Obese | |||||
(n = 185) | (n = 199) | n = 185 | n = 199 | |||||||||||||
Blood Biochemistry (mg/dL) | ||||||||||||||||
Glucose | 84.86 ± 20.29 | 97.21 ± 32.72 | 0.000 | 81.21 ± 10.92 | 96.83 ± 31.53 | 0.000 | 0.163 | 0.563 | 85.02 ± 20.32 | 97.54 ± 33.28 | 0.001 | 81.00 ± 10.94 | 96.47 ± 30.88 | 0.000 | 0.097 | 0.816 |
Cholesterol | 229.19 ± 52.14 | 236.69 ± 57.20 | 0.440 | 228.75 ± 52.10 | 238.10 ± 70.27 | 0.584 | 0.865 | 0.787 | 230.06 ± 52.44 | 238.51 ± 57.27 | 0.360 | 227.37 ± 51.57 | 235.89 ± 69.65 | 0.660 | 0.621 | 0.772 |
HDL | 70.27 ± 13.28 | 60.63 ± 12.78 | 0.000 | 70.36 ± 7.53 | 61.57 ± 11.78 | 0.000 | 0.780 | 0.420 | 70.28 ± 13.32 | 60.66 ± 12.92 | 0.000 | 70.34 ± 14.52 | 61.49 ± 11.65 | 0.000 | 0.755 | 0.640 |
Triglyceride | 90.52 ± 56.09 | 122.43 ± 62.73 | 0.000 | 90.61 ± 46.54 | 115.26 ± 58.92 | 0.001 | 0.652 | 0.402 | 90.75 ± 56.26 | 121.52 ± 61.31 | 0.000 | 90.23 ± 46.41 | 116.64 ± 60.95 | 0.001 | 0.703 | 0.576 |
LDL | 140.81 ± 47.48 | 151.57 ± 54.08 | 0.226 | 140.26 ± 47.96 | 153.47 ± 66.04 | 0.388 | 0.795 | 0.770 | 141.62 ± 47.84 | 153.54 ± 54.07 | 0.150 | 138.98 ± 47.34 | 151.07 ± 65.55 | 0.494 | 0.585 | 0.772 |
Homa-IR | 2.70 ± 2.03 | 3.97 ± 1.48 | 0.000 | 2.48 ± 0.61 | 4.12 ± 2.96 | 0.000 | 0.384 | 0.638 | 2.71 ± 2.03 | 3.98 ± 1.51 | 0.000 | 2.47 ± 0.61 | 4.11 ± 2.89 | 0.000 | 0.340 | 0.681 |
Blood Inflammation and Hormone | ||||||||||||||||
TNF-alpha (pg/mL) | 35.73 ± 2.83 | 47.06 ± 14.00 | 0.000 | 35.51 ± 2.89 | 45.52 ± 6.35 | 0.000 | 0.462 | 0.940 | 35.70 ± 2.90 | 47.01 ± 14.26 | 0.000 | 35.58 ± 2.78 | 45.64 ± 6.25 | 0.000 | 0.536 | 0.397 |
IL-6 (pg/mL) | 39.24 ± 3.16 | 43.24 ± 4.13 | 0.000 | 39.37 ± 3.93 | 43.27 ± 6.50 | 0.000 | 0.776 | 0.529 | 39.27 ± 3.17 | 43.22 ± 7.19 | 0.000 | 39.33 ± 3.91 | 43.29 ± 6.35 | 0.000 | 0.973 | 0.941 |
Myeloperoxidase (ng/mL) | 119.52 ± 29.89 | 137.23 ± 43.59 | 0.000 | 117.21 ± 21.83 | 149.29 ± 76.81 | 0.000 | 0.628 | 0.074 | 119.93 ± 30.40 | 137.01 ± 44.38 | 0.000 | 116.60 ± 20.76 | 149.02 ± 75.09 | 0.000 | 0.560 | 0.165 |
Leptin (ng/mL) | 2.02 ± 0.60 | 3.97 ± 0.92 | 0.000 | 2.07 ± 0.55 | 4.23 ± 0.94 | 0.000 | 0.650 | 0.258 | 2.03 ± 0.61 | 3.96 ± 0.93 | 0.000 | 2.05 ± 0.53 | 4.23 ± 0.92 | 0.000 | 0.997 | 0.043 |
Insulin (uIU/mL) | 12.8 ± 4.03 | 16.69 ± 2.48 | 0.000 | 12.70 ± 2.00 | 16.98 ± 5.25 | 0.000 | 0.519 | 0.876 | 12.89 ± 4.05 | 16.65 ± 2.51 | 0.000 | 12.66 ± 1.98 | 17.01 ± 5.14 | 0.000 | 0.697 | 0.528 |
