Table 2 Prevalence of colonisation for the seven CF pathogens of interest during the 3 years before and the year after the initiation of ETI. Colonisation was defined by the positivity of at least one sputum during the year (Y-2: status 2 years before ETI introduction, Y-1: status 1 year before ETI introduction, Y0: status at ETI introduction, Y + 1: status the year following ETI introduction).
From: One year of ETI reduces lung bacterial colonisation in adults with cystic fibrosis
Y-2 N = 194 | Y-1 N = 196 | Y0 N = 198 | Y + 1 N = 179 | p-value1 | |
|---|---|---|---|---|---|
Number of sputum culture -mean (SD) | 4.4 (2.0) | 3.9 (1.7) | 4.5 (1.8) | 3.1 (1.7) |
% (n) [95% CI] | % (n) [95% CI] | % (n) [95% CI] | % (n) [95% CI] | ||
|---|---|---|---|---|---|
Pseudomonas aeruginosa | 69.0 (134) [62–75] | 73.0 (144) [67–79] | 72.0 (142) [65–78] | 59.0 (105) [51–66] | < 0.001 |
MRSA | 12.0 (23) [7.8–17] | 11.0 (22) [7.3–17] | 9.6 (19) [6.0–15] | 4.5 (8) [2.1–8.9] | < 0.001 |
MSSA | 74.0 (144) [67–80] | 73.0 (144) [67–79] | 71.0 (141) [64–77] | 64.0 (115) [57–71] | 0.012 |
Haeomophilus influenzae | 8.8 (17) [5.3–14] | 11.0 (21) [6.9–16] | 5.6 (11) [2.9–10] | 8.4 (15) [4.9–14] | 0.9 |
Stenotrophomonas maltophilia | 21.0 (40) [15–27] | 15.0 (29) [10–21] | 19.0 (37) [14–25] | 7.3 (13) [4.1–12] | < 0.001 |
Achromobacter spp. | 15.0 (29) [10–21] | 17.0 (33) [12–23] | 16.0 (32) [11–22] | 11.0 (20) [7.2–17] | 0.007 |
Burkholderia cepacia complex species | 5.7 (11) [3.0–10] | 7.1 (14) [4.1–12] | 6.6 (13) [3.7–11] | 5.0 (9) [2.5–9.6] | 0.13 |
Nontuberculous mycobacteria | 7.2 (14) [4.2–12] | 8.7 (17) [5.3–14] | 10.0 (20) [6.4–15] | 1.7 (3) [0.44–5.2] | < 0.001 |
Any of the bacteria above | 99.0 (193) [97–100] | 99.0 (194) [96–100] | 98.0 (195) [95–100] | 90.0 (161) [84–94] | < 0.001 |
