Table 1 Average ± SEM.

From: ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice

 

db/misty control

db/misty ASK-1 inhibitor

eNOS-KO db/db control

eNOS-KO db/db ASK-1 inhibitor

BW (g)

28.6 ± 1.3

22.7 ± 0.3

50.0 ± 1.4*

36.9 ± 1.7*

BS (mg/dL)

148 ± 10

111 ± 9

368 ± 58*

380 ± 41*

BP (mmHg)

106 ± 1

98 ± 4

141 ± 13

137 ± 21

s-Cr (mg/dL)

0.10 ± 0.006

0.14 ± 0.005

0.10 ± 0.007

0.09 ± 0.007

BUN (mg/dL)

41.0 ± 3.0

32.0 ± 2.0

43.8 ± 2.9

35.3 ± 1.5

  1. BW Body weight, BS Blood sugar, BP Blood pressure.
  2. *P < 0.05 vs. db/misty control.
  3. P < 0.05 vs.eNOS-KO/db/db control.