Table 6 Drug release data fitting to different mathematical models for interpretation of drug release kinetics and mechanism.

From: Self-assembled latanoprost loaded soluplus nanomicelles as an ophthalmic drug delivery system for the management of glaucoma

Model

R2

SSR

Model k (or Model k1)

Model k2

Model y-intercept

Model n

AIC n

AIC k

AIC

Zero-Order

0.765

0.122

0.607

N/A1

0.378

N/A

7

2

−2.40

First-Order

0.933

0.0347

0.512

N/A

1

N/A

7

1

−8.22

Korsmeyer-Peppas

0.968

0.0167

0.456

N/A

0

0.335

7

2

−8.44

Higuchi

0.998

0.000477

0.412

N/A

0.0265

N/A

5

2

−10.6

Peppas and Sahlin

0.928

0.0371

0.264

1.39 × 10−12

0.171

 N/A

7

3

−4.01

Peppas and Sahlin2

0.929

0.0158

0.478

3.00 × 10−12

−0.0278

N/A

7

3

−6.61

Hixson-Crowell

0.971

0.0149

0.0681

N/A

1.03

N/A

7

2

−8.79

Hixson-Crowell3

0.827

0.0885

0.0856

N/A

1.17

N/A

7

1

−5.37

  1. AIC, Akaike information criterion; SSR, Sum of Squares Regression; R2, coefficient of determination.
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