Table 7 Stability studies of optimized nanomicelles.

From: Self-assembled latanoprost loaded soluplus nanomicelles as an ophthalmic drug delivery system for the management of glaucoma

Time

Storage temperature 4 °C

Storage temperature 25 °C

Particle size

PDI

EE%

ZP

Drug content

Particle size

PDI

EE%

ZP

Drug content

Day 1

69 ± 0.05

0.02 ± 0.02

77.53 ± 0.05

−313 ± 0.02

99.6 ± 0.1

69.43 ± 0.06

0.02 ± 0.01

77.53 ± 0.05

−13.3 ± 0.05

99.5 ± 0.1

Week 1

69.2 ± 0.1

0.02 ± 0.01

77.4 ± 0.1

−13.1 ± 0.04

99.2 ± 0.5

78.2 ± 0.5

0.03 ± 0.02

77.23 ± 0.05

−11.6 ± 0.1

99.2 ± 0.5

Week 2

70.4 ± 0.2

0.03 ± 0.02

77.2 ± 0.1

−13.0 ± 0.05

98.7 ± 0.1

84.87 ± 0.2

0.39 ± 0.5

76.8 ± 0.1

−10.3 ± 0.06

98.6 ± 0.1

Week 3

71.1 ± 0.2

0.12 ± 0.08

77.03 ± 0.5

−12.9 ± 0.06

98.7 ± 0.2

88 ± 0.2

0.43 ± 0.06

76.2 ± 0.1

−8.6 ± 0.1

98.8 ± 0.2

Week 4

71.6 ± 0.5

0.16 ± 0.04

76.8 ± 0.3

−12.0 ± 0.1

98.1 ± 0.1

93.3 ± 0.6

0.51 ± 0.1

75.5 ± 0.2

−5 ± 0.2

98.4 ± 0.25

Week 8

72.53 ± 0.5

0.13 ± 0.5

75.16 ± 0.15

−11.7 ± 0.1

98.1 ± 0.2

99.2 ± 0.6

0.44 ±0.05

73.5 ± 0.5

−3.4 ±0.52

98.2 ± 0.24

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