Table 1 Core target information.

From: Mechanism of action of Salvia miltiorrhiza on avascular necrosis of the femoral head determined by integrated network pharmacology and molecular dynamics simulation

NO.

Gene names

Uniprot ID

Protein names

Degree

Betweenness

Closeness

1

TP53

P04637

Cellular tumor antigen p53

37

63.37255046

0.022222222

2

AKT1

P31749

RAC-alpha serine/threonine-protein kinase

36

40.12132212

0.02173913

3

EGFR

P00533

Epidermal growth factor receptor

36

91.13654959

0.02173913

4

STAT3

P40763

Signal transducer and activator of transcription 3

35

27.94734729

0.021276596

5

BCL2

P10415

Bcl-2-like protein 1

35

27.94734729

0.021276596

6

IL6

P05231

Interleukin-6

35

35.50019163

0.021276596

7

TNF

P01375

Tumor necrosis factor

35

35.50019163

0.021276596

8

CASP3

P42574

Caspase-3

34

22.55379284

0.020833333

9

JUN

P05412

Transcription factor AP-1

34

23.62823745

0.020833333

10

MMP9

P14780

Matrix metalloproteinase-9

34

54.74226749

0.020833333

11

ESR1

P03372

Estrogen receptor

34

27.40655494

0.020833333

12

PTGS2

P35354

Prostaglandin G/H synthase 2

33

21.08910339

0.020408163

13

MYC

P01106

Myc proto-oncogene protein

32

64.96274475

0.02

14

IFNG

P01579

Interferon gamma

31

18.73288241

0.019607843

15

PPARG

P37231

Peroxisome proliferator-activated receptor gamma

31

18.1670033

0.019607843

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