Table 3 List of text verification results for the top 10 key targets based on domain knowledge scores.
Fish oil | Forskolin | ||||
|---|---|---|---|---|---|
Target name | Correlation effect | Domain knowledge score | Target name | Correlation effect | Domain knowledge score |
CCNA2 | Regulator of the cell cycle | 1 | CCNA2 | Regulator of the cell cycle | 1 |
CCNB1 | Involved in controlling the transition phase of the cell cycle from G2 to M | 0 | CCNB1 | Involved in controlling the transition phase of the cell cycle from G2 to M | 0 |
IL6 | Associated with a variety of inflammatory - related disease states | 243 + 49 + 16 | CXCL8 | A major mediator of the inflammatory response | 9 + 1 + 0 |
ESR1 | Regulate the transcription of many estrogen induced genes | 16 + 0 + 0 | VEGFA | Induce endothelial cell proliferation, promote cell migration and inhibit cell apoptosis | 14 + 1 + 0 |
IL1B | An important agent of inflammatory response and is involved in a variety of cellular activities | 15 + 1 | FOS | Regulator of cell proliferation, differentiation and transformation. Associated with apoptotic cell death. | 109 + 12 + 1 |
IL10 | Play a pleiotropic role in immune regulation and inflammation | 98 + 20 + 11 | HDAC1 | Involved in cell proliferation and differentiation, cell growth and apoptosis | 10 + 2 + 7 |
BRCA1 | Maintain genomic stability and act as a tumor suppressor | 4 | IGF1 | A member of a family of proteins involved in mediating growth and development | 74 + 4 + 3 |
CCND1 | Involved in cell cycle processes | 3 | CYCS | Involved in the initiation of apoptosis | 0 |
BUB1 | Play a central role in mitosis | 3 | CEBPB | Play an important role in regulating genes involved in immune and inflammatory responses, among other processes | 1 |
MKI67 | Associated with cell proliferation | 0 | PPARGC1A | Regulate the genes involved in energy metabolism | 3 + 0 + 0 |
NTRK2 (TRKB ) | Send signals to the cell that lead to differentiation | 9 | PTGS2 | Responsible for prostaglandin biosynthesis involved in inflammation and mitosis | 23 + 1 + 0 |
PLK1 | Involved in mitosis and apoptosis | 2 | |||
TOP2A | Involved in processes such as chromosome condensation, chromatid separation, and relief of torsional stress during DNA transcription and replication | 2 | |||
