Table 3 Univariate and multivariate of clinical parameters associated with ER in HCC patients without MVI after R0 resection.
From: Nomogram for predicting early recurrence of hepatocellular carcinoma with narrow resection margin
Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | 95%CI | P-value | HR | 95%CI | p-value | |
Age (year), ≥ 60 vs. < 60 | 0.96 | 0.83–1.11 | 0.576 | / | / | / |
Gender, male vs. female | 1.09 | 0.91–1.31 | 0.365 | / | / | / |
Smoking, years ≥ 10 vs. < 10 | 0.98 | 0.86–1.12 | 0.782 | / | / | / |
Alcohol consumption, years ≥ 10 vs. < 10 | 1.05 | 0.90–1.22 | 0.533 | / | / | / |
Hypertension, yes vs. no | 0.85 | 0.70–1.03 | 0.095 | / | / | / |
Diabetes Mellitus, yes vs. no | 0.83 | 0.62–1.10 | 0.189 | / | / | / |
Liver cirrhosis, absence/presence | 1.02 | 0.89–1.17 | 0.746 | / | / | / |
HBsAg, positive vs. negative | 1.27 | 1.02–1.57 | 0.029 | 1.33 | 1.06–1.67 | 0.013 |
AFP (µg/L), ≥ 400 vs. < 400 | 1.93 | 1.70–2.19 | < 0.001 | 1.47 | 1.28–1.68 | < 0.001 |
HBVDNA (IU/mL), ≥ 1000 vs. < 1000 | 1.26 | 1.04–1.53 | 0.020 | 1.09 | 0.89–1.34 | 0.386 |
WBC (× 109/L), ≥ 4 vs. < 4 | 1.15 | 0.98–1.36 | 0.082 | / | / | / |
PLT (× 109/L), ≥ 100 vs. < 100 | 1.02 | 0.86–1.22 | 0.781 | / | / | / |
ALB (g/L), ≥ 35 vs. < 35 | 0.56 | 0.40–0.80 | 0.001 | 0.80 | 0.56–1.16 | 0.247 |
TBil (µmol/L), ≥ 17 vs. < 17 | 1.20 | 1.04–1.38 | 0.013 | 1.16 | 1.00-1.34 | 0.052 |
GGT(U/L), ≥ 50 vs. < 50 | 1.80 | 1.57–2.06 | < 0.001 | 1.21 | 1.04–1.41 | 0.015 |
ALP(U/L), ≥ 80 vs. < 80 | 1.74 | 1.53–1.99 | < 0.001 | 1.26 | 1.09–1.46 | 0.002 |
ALBI grade, II vs. I | 1.38 | 1.20–1.59 | < 0.001 | 1.14 | 0.98–1.33 | 0.648 |
Surgical method, major hepatectomy vs. minor hepatectomy | 2.65 | 2.31–3.03 | < 0.001 | 1.28 | 1.00-1.63 | 0.052 |
Blood transfusion, yes vs. no | 2.07 | 1.73–2.48 | < 0.001 | 1.06 | 0.81–1.39 | 0.648 |
Operative bleeding loss (mL), ≥ 800 vs. < 800 | 2.10 | 1.73–2.56 | < 0.001 | 1.18 | 0.88–1.58 | 0.272 |
Tumor size (cm) | ||||||
5–10 vs. < 5 | 2.25 | 1.94–2.61 | < 0.001 | 2.06 | 1.75–2.41 | < 0.001 |
> 10 vs. < 5 | 3.95 | 3.32–4.71 | < 0.001 | 2.26 | 1.66–3.09 | < 0.001 |
Tumor number, multiple vs. single | 2.12 | 1.84–2.45 | < 0.001 | 1.61 | 1.35–1.92 | < 0.001 |
Microvascular invasion, presence/ absence | 2.11 | 1.86–2.40 | < 0.001 | 1.73 | 1.51–1.98 | < 0.001 |
Edmondson-Steiner grade, III-IV vs. I-II | 1.86 | 1.51–2.30 | < 0.001 | 1.11 | 0.89–1.38 | 0.368 |
Tumor capsular, absence/presence | 1.42 | 1.20–1.68 | < 0.001 | 1.35 | 1.14–1.61 | 0.001 |
Satellite nodules, presence/ absence | 1.83 | 1.62–2.08 | < 0.001 | 1.30 | 1.11–1.52 | 0.001 |
Antiviral therapy, yes vs. no | 0.72 | 0.63–0.82 | < 0.001 | 0.87 | 0.76-1.00 | 0.047 |
Postoperative TACE, yes vs. no | 1.08 | 0.95–1.23 | 0.249 | / | / | / |
