Fig. 2

Metachronous RC and differential gene expression in the cancerization field ((IMMUNOREACT 9: whole cohort). (A) Volcano plot of differential gene expression in the cancerization field of metachronous RC patients (n = 3) vs. non-metachronous RC patients (n = 30). The 20 statistically significant genes are labeled in the plot. (B) Differential expression of gene-based cell types abundance scores in the cancerization field of metachronous RC patients vs. non-metachronous RC patients. (C) Differential expression of gene signatures pathways scores in the cancerization field of metachronous RC patients vs. non-metachronous RC patients.