Table 1 Baseline information table based on all-cause mortality and CVD mortality subgroups.

NPAR

14.19 ± 0.06

14.05 ± 0.06

15.22 ± 0.15

< 0.001

14.14 ± 0.06

15.75 ± 0.28

< 0.001

Q1 (≤ 12.45)

992 (24.17)

895 (25.20)

97 (16.47)

963 (24.53)

29 (13.95)

Q2 (12.45–14.08)

993 (24.61)

882 (25.56)

111 (17.53)

963 (24.95)

30 (15.00)

Q3 (14.08–15.72)

992 (25.65)

846 (25.66)

146 (25.55)

950 (25.74)

42 (23.08)

Q4 (> 15.72)

993 (25.57)

757 (23.58)

236 (40.45)

911 (24.78)

82 (47.97)

lnSII

6.22 ± 0.01

6.21 ± 0.01

6.31 ± 0.04

< 0.001

6.21 ± 0.01

6.42 ± 0.06

< 0.001

Q1 (≤ 5.85)

992 (22.72)

855 (22.62)

137 (23.51)

953 (22.90)

39 (17.64)

Q2 (5.85–6.18)

997 (24.64)

887 (25.72)

110 (16.56)

970 (24.97)

27 (15.35)

Q3 (6.18–6.53)

988 (24.92)

844 (25.13)

144 (23.40)

943 (24.97)

45 (23.49)

Q4 (> 6.53)

993 (27.71)

794 (26.53)

199 (36.53)

921 (27.15)

72 (43.52)

NLR

2.29 ± 0.02

2.22 ± 0.02

2.81 ± 0.09

< 0.001

2.26 ± 0.02

3.03 ± 0.12

< 0.001

Q1 (≤ 1.53)

990 (22.99)

895 (23.87)

95 (16.42)

968 (23.44)

22 (10.50)

Q2 (1.53-2)

1017 (24.72)

897 (25.50)

120 (18.82)

983 (24.96)

34 (17.89)

Q3 (2-2.67)

985 (25.81)

855 (26.55)

130 (20.31)

949 (26.07)

36 (18.54)

Q4 (> 2.67)

978 (26.48)

733 (24.08)

245 (44.45)

887 (25.54)

91 (53.07)

Age (years)

51.48 ± 0.39

49.26 ± 0.40

68.08 ± 0.74

< 0.001

50.82 ± 0.38

69.85 ± 1.01

< 0.001

Sex

0.060

0.680

Female

1819 (44.17)

1601 (44.78)

218 (39.58)

1746 (44.24)

73 (42.30)

Male

2151 (55.83)

1779 (55.22)

372 (60.42)

2041 (55.76)

110 (57.70)

Race

< 0.001

0.050

Non-Hispanic white

1757 (67.95)

1372 (66.51)

385(78.71)

1646 (67.67)

111 (75.77)

Non-Hispanic black

448 (6.51)

391 (6.60)

57 (5.79)

426 (6.47)

22 (7.48)

Mexican American

1006 (13.71)

924 (14.59)

82 (7.12)

978 (13.87)

28 (9.05)

Other race

759 (11.84)

693 (12.30)

66 (8.39)

737 (11.99)

22 (7.69)

Education level

< 0.001

0.001

 < High school

1368 (23.92)

1119 (22.34)

249 (35.68)

1290 (23.46)

78 (36.87)

High school

902 (23.81)

750 (23.50)

152 (26.07)

854 (23.79)

48 (24.39)

> High school

1700 (52.28)

1511 (54.15)

189 (38.26)

1643 (52.76)

57 (38.74)

PIR

< 0.001

 < 1.3

1498 (25.20)

1260 (24.53)

238 (30.23)

< 0.001

1435 (25.12)

63 (27.44)

 1.3–3.5

1500 (38.73)

1237 (37.31)

263 (49.39)

1405 (38.16)

95 (54.77)

≥ 3.5

972 (36.07)

883 (38.16)

89 (20.38)

947 (36.71)

25 (17.79)

Physical activity

< 0.001

< 0.001

No

2423 (56.73)

1985 (54.33)

438 (74.68)

2289 (56.10)

134 (74.58)

Moderate

1051 (29.35)

926 (30.49)

125 (20.79)

1010 (29.63)

41 (21.42)

Rigorous

496 (13.92)

469 (15.17)

27 (4.53)

488 (14.27)

8 (4.00)

Smoking status

< 0.001

0.340

Never

2116 (52.19)

1880 (53.88)

236 (39.55)

2031 (52.41)

85 (46.03)

Past

1176 (30.43)

924 (29.03)

252 (40.91)

1105 (30.21)

71 (36.54)

Current

678 (17.38)

576 (17.09)

102 (19.54)

651 (17.38)

27 (17.43)

CVD

< 0.001

< 0.001

No

3299 (85.46)

2949 (88.97)

350 (59.19)

3206 (86.65)

93 (51.92)

Yes

671 (14.54)

431 (11.03)

240 (40.81)

581 (13.35)

90 (48.08)

CKD

< 0.001

< 0.001

No

3532 (91.24)

3146 (94.12)

386 (69.67)

3430 (92.37)

102 (59.39)

Yes

438 (8.76)

234 (5.88)

204 (30.33)

357 (7.63)

81 (40.61)

DM

< 0.001

< 0.001

No

651 (19.49)

604 (21.06)

47 (7.74)

637 (19.94)

14 (6.73)

Pre-DM

1928 (50.86)

1691 (51.75)

237 (44.24)

1847 (50.92)

81 (49.33)

DM

1391 (29.65)

1085 (27.19)

306 (48.02)

1303 (29.14)

88 (43.94)

Hypertension

< 0.001

< 0.001

No

1713 (44.96)

1570 (47.50)

143 (25.91)

1680 (45.91)

33 (18.07)

Yes

2257 (55.04)

1810 (52.50)

447 (74.09)

2107 (54.09)

150 (81.93)

COPD

< 0.001

< 0.001

No

3574 (89.98)

3091 (91.41)

483 (79.31)

3423 (90.37)

151 (79.00)

Yes

396 (10.02)

289 (8.59)

107 (20.69)

364 (9.63)

32 (21.00)

BMI (kg/m²)

34.65 ± 0.18

34.88 ± 0.20

32.97 ± 0.32

< 0.001

34.70 ± 0.19

33.32 ± 0.55

0.020

WC (cm)

114.31 ± 0.39

114.40 ± 0.43

113.66 ± 0.76

0.380

114.32 ± 0.41

114.08 ± 1.30

0.860

ALT (IU/L)

31.35 ± 0.40

32.22 ± 0.42

24.82 ± 1.00

< 0.001

31.59 ± 0.41

24.47 ± 2.96

0.020

AST (IU/L)

27.10 ± 0.27

27.13 ± 0.28

26.84 ± 0.88

0.760

27.12 ± 0.28

26.56 ± 2.40

0.820

GGT (IU/L)

37.50 ± 0.62

37.26 ± 0.68

39.35 ± 1.89

0.310

37.53 ± 0.64

36.85 ± 2.60

0.800

FBG (mmol/L)

6.75 ± 0.05

6.65 ± 0.04

7.57 ± 0.18

< 0.001

6.73 ± 0.05

7.49 ± 0.30

0.010

HbA1c (%)

6.05 ± 0.03

5.99 ± 0.03

6.48 ± 0.09

< 0.001

6.03 ± 0.03

6.55 ± 0.18

0.004

FINS (µU/mL)

24.24 ± 0.43

24.24 ± 0.47

24.22 ± 0.99

0.990

24.23 ± 0.43

24.62 ± 1.91

0.830

TG (mg/dL)

172.01 ± 2.92

172.41 ± 3.03

168.96 ± 6.26

0.590

172.20 ± 2.98

166.49 ± 8.89

0.530

TC (mg/dL)

195.01 ± 0.94

196.28 ± 0.97

185.48 ± 2.09

< 0.001

195.36 ± 0.94

184.97 ± 5.14

0.050

HDL-C (mg/dL)

45.61 ± 0.24

45.38 ± 0.24

47.33 ± 0.74

0.010

45.55 ± 0.24

47.16 ± 1.27

0.220

LDL-C (mg/dL)

116.43 ± 0.83

117.80 ± 0.86

106.18 ± 1.98

< 0.001

116.81 ± 0.81

105.73 ± 4.60

0.020

Platelet count (10⁹/L)

250.92 ± 1.28

252.87 ± 1.45

236.32 ± 3.76

< 0.001

251.24 ± 1.31

241.63 ± 7.77

0.230

Albumin (g/dL)

4.20 ± 0.01

4.21 ± 0.01

4.09 ± 0.02

< 0.001

4.20 ± 0.01

4.05 ± 0.03

< 0.001

Neutrophil percentage (%)

59.18 ± 0.21

58.84 ± 0.21

61.69 ± 0.56

< 0.001

59.04 ± 0.21

63.04 ± 0.78

< 0.001

Lymphocyte count (10⁹/L)

2.14 ± 0.02

2.16 ± 0.02

1.99 ± 0.05

0.002

2.15 ± 0.02

1.91 ± 0.08

0.003

Neutrophil count (10⁹/L)

4.49 ± 0.04

4.45 ± 0.04

4.83 ± 0.12

0.002

4.47 ± 0.04

5.03 ± 0.16

< 0.001