Fig. 3 | Scientific Reports

Fig. 3

From: Effects of Empagliflozin and Dapagliflozin in alleviating cardiac fibrosis through SIRT6-mediated oxidative stress reduction

Fig. 3

Empagliflozin and Dapagliflozin suppress TGF-β1-induced proliferation and phenotypic transformation of CFs. (A-B) Effect of EMPA and DAPA pretreatment on the proliferation rate of TGF-β1-induced CFs. (C-D) Western blot analysis of protein expression levels in CFs following pretreatment with EMPA/DAPA and subsequent induction by TGF-β1. (E) Immunofluorescence detection of α-SMA expression in CFs induced by TGF-β1 after pretreatment with 10 μM EMPA/DAPA. Each experiment was repeated three times (n = 3). *P < 0.05, ***P < 0.001 vs. CN group, #P < 0.05, ##P < 0.01, ###P < 0.001 vs. TGF-β1 group. Of note, CN  control, EMPA  empagliflozin, DAPA  dapagliflozin. Original blots are presented in Supplementary Information for Western blot Original Data.

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