Fig. 2
From: Clusterin inhibits lipopolysaccharide induced liver injury
Effect of clusterin deficiency on NLRP3 inflammasome activation in LPS-injected mice. (A) ELISA analysis of IL1-β and IL-18 levels in serum from wild-type and Clu-KO mice injected with LPS for 3 h. (B) Representative real-time PCR analysis of IL-1β and NLRP3 in WT and Clu-KO mice treated with and without LPS. (C) Immunohistochemical staining for IL-1β in liver sections of LPS-treated Clu-KO mice. (D) Representative western blot analysis of NLRP3 and ASC proteins in the liver of Clu-KO mice after LPS injection. *p < 0.05, **p < 0.01, ***p < 0.001.
