Fig. 1
From: Metabolomics analysis reveals resembling metabolites between humanized γδ TCR mice and human plasma
Determination of non-targeted metabolomics and lipidomics in plasma samples. A heatmap of top 100 significant metabolites in plasma samples visualizes the intensity of metabolites. The magnitude of a metabolite is arranged to show their relatedness in the cluster heatmap. In addition, the more intense yellow color represents the higher magnitude, while the red color represents the lower magnitude of a metabolite. Humanized gamma-delta (γδ) transgenic mice were generated using BAC genomic DNA platform (> 100 kb). Plasma samples were prepared using the cold methanol extraction method, analyzed with UHPLC-MS/MS, and analyzed using MetaboAnalyst 5.0. Human Kyoto Encyclopedia of Genes and Genomes (KEGG) and Human Metabolome Database (HMBD) were used to match putative metabolites and/or pathways.
