Fig. 1 | Scientific Reports

Fig. 1

From: Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping

Fig. 1

Flow cytometric analysis of Th immune profile reveals a unique immune cell phenotype in erythroderma of unknown etiology. (A) Clinical presentation of index patient and erythrodermic controls. PRP, pityriasis rubra pilaris; SS, Sézary syndrome. (B) PBMC and whole blood flow cytometry study design. (C) Representative flow plots of stimulated or unstimulated CD3 + T cells expressing Th cytokines (IL-4, IL-13, IL-17, and IFN-γ) (D) Representative flow plots of stimulated or unstimulated CD3 + T cells expressing TGF-β and IL-10 in the index patient and controls. (E) Bar plots showing percentages of patient immune cell populations, stratified by percentage of IL-13-producing or IL-17-producing T cells.

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