Table 3 Physicochemical characterization of clozapine transdermal formulations (mean ± SD, n = 6).

From: Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Formulation code

Weight (mg)

Thickness (mm)

Folding endurance

% Moisture content

% Moisture uptake

% Drug content

F1

186.166 ± 1.094

0.120 ± 0.010

> 300

1.236 ± 0.058

0.950 ± 0.030

91.986 ± 1.090

F2

265.937 ± 1.747

0.180 ± 0.010

> 300

1.123 ± 0.256

0.393 ± 0.102

90.21 ± 1.39

F3

345.813 ± 1.580

0.250 ± 0.010

> 300

0.500 ± 0.055

0.956 ± 0.011

93.870 ± 0.910

F4

196.343 ± 2.152

0.146 ± 0.011

> 300

0.756 ± 0.041

1.216 ± 0.100

90.923 ± 0.647

F5

277.760 ± 0.907

0.213 ± 0.015

> 300

0.630 ± 0.219

0.856 ± 0.015

90.053 ± 0.473

F6

266.136 ± 2.128

0.180 ± 0.010

> 300

0.950 ± 0.165

0.896 ± 0.133

91.656 ± 0.682

F7

195.370 ± 1.903

0.156 ± 0.015

> 300

1.170 ± 0.173

0.850 ± 0.199

92.30 ± 0.667

F8

265.530 ± 2.023

0.183 ± 0.005

> 300

1.090 ± 0.291

0.393 ± 0.102

89.876 ± 1.291

F9

393.437 ± 0.858

0.270 ± 0.010

> 300

0.533 ± 0.106

0.856 ± 0.179

91.870 ± 4.184

F10

265.343 ± 2.150

0.190 ± 0.010

> 300

0.756 ± 0.041

1.216 ± 0.100

89.923 ± 1.356

F11

335.762 ± 2.095

0.240 ± 0.010

> 300

0.563 ± 0.106

0.856 ± 0.015

90.38 ± 3.976

F12

266.470 ± 0.978

0.186 ± 0.005

> 300

0.950 ± 0.165

0.896 ± 0.133

92.323 ± 0.516

F13

266.270 ± 0.905

0.176 ± 0.015

> 300

1.203 ± 0.066

0.916 ± 0.085

91.300 ± 0.561

F14

186.770 ± 1.556

0.130 ± 0.010

> 300

1.023 ± 0.083

0.393 ± 0.102

90.210 ± 1.391

F15

346.343 ± 2.150

0.240 ± 0.010

> 300

0.500 ± 0.055

0.956 ± 0.011

93.203 ± 1.929

F16

258.093 ± 1.547

0.173 ± 0.011

> 300

0.756 ± 0.041

0.983 ± 0.064

91.256 ± 1.131

F17

266.136 ± 1.860

0.173 ± 0.015

> 300

0.563 ± 0.106

0.856 ± 0.015

90.053 ± 0.473

F18

265.883 ± 1.615

0.186 ± 0.005

> 300

0.950 ± 0.165

0.896 ± 0.133

93.990 ± 3.381

F19

336.760 ± 1.998

0.233 ± 0.005

> 300

0.816 ± 0.068

0.896 ± 0.133

92.656 ± 1.080

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