Table 4 Probability value of responses and polynomial equation of constraints.

From: Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Response

p-value

Model

X1

X2

X3

Y1

0.0014

0.3261

0.0002

0.7516

Y2

< 0.0001

0.4593

0.4473

< 0.0001

Y3

< 0.0001

< 0.0001

0.9661

0.7454

Polynomial equation of the constraints

Y1 = 1.08 +  − 0.0244 X1 + 0.1061 X2 + 0.0069 X3

Y2 = 148.95 +  − 1.46 X1 + 1.33 X2 + 14.56 X3

Y3 = 92.29 +  − 17.12 X1 + 0.0833 X2 + 0.6373 X3

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