Table 5 Permeation parameters of different formulations of clozapine patches.

From: Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Formulations

Permeation Parameters

Lag time (h)

Permeation coefficient (cm/h)

Diffusion coefficient (cm2/h)

F1

0.723

3.15E-02

2.07E-04

F2

0.603

3.30E-02

2.49E-04

F3

0.711

3.11E-02

2.11E-04

F4

0.617

3.86E-02

2.43E-04

F5

0.714

3.50E-02

2.10E-04

F6

0.618

4.21E-02

2.43E-04

F7

0.687

3.12E-02

2.18E-04

F8

0.903

3.37E-02

1.66E-04

F9

0.528

3.56E-02

2.84E-04

F10

0.918

3.47E-02

1.63E-04

F11

0.956

3.26E-02

1.57E-04

F12

0.969

3.30E-02

1.55E-04

F13

0.863

3.44E-02

1.74E-04

F14

0.860

3.98E-02

1.74E-04

F15

0.728

3.78E-02

2.06E-04

F16

0.635

3.28E-02

2.36E-04

F17

1.087

3.46E-02

1.38E-04

F18

2.853

2.89E-02

5.26E-05

F19

1.315

3.41E-02

1.14E-04

Back to article page