Table 6 Composition of optimized clozapine transdermal patch with observed and predicted values.

From: Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

X1(mg)

X2(%)

X3(%)

Y1 (Kg/cm2)

Y2 (µg/cm2h)

Y3 (%)

Observed

Predicted

Observed

Predicted

Observed

Predicted

154.064

10.741

1.043

1.220

0.971

147.376

133.936

94.874

85

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