Table 8 Assessment of clozapine transdermal patches in optimized formulation through open field activity, rearing test and force swimming test in rats (mean ± SEM, n = 5).

From: Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches

Test animal

Open field activity

Rearing

Immobility (s)

Control (Group I)

165.431 ± 2.953

50.396 ± 1.311

103 ± 15

Standard (Group II)

178.153 ± 1.625

62.180 ± 1.220

70 ± 08

Test (Group III)

174.760 ± 2.110

59.261 ± 1.233

82 ± 09

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