Table 9 Observed vs predicted values of pharmacokinetic parameters for IV, oral, and transdermal patches of clozapine.
Pharmacokinetic parameters | IV (25 mg) | Oral (75 mg) | Transdermal (50 mg) | |||||
|---|---|---|---|---|---|---|---|---|
Observed | Predicted | Fold error | Observed | Predicted | Fold error | Predicted | Fold error | |
Cmax (ng/mL) | 2521.800 | 2999.200 | 0.840 | 81.986 | 50.236 | 1.630 | 38.396 | 2.130 |
Tmax (h) | 0.024 | 0.014 | 1.000 | 2.853 | 5.060 | 0.560 | 28.960 | 0.100 |
AUC0-inf (ng-h/mL) | 990.750 | 920.570 | 1.080 | 985.180 | 1077 | 0.910 | 1625.500 | 0.600 |
AUC0-t (ng-h/mL) | 980.880 | 910.420 | 1.080 | 956.660 | 945.460 | 1.010 | 1175.700 | 0.810 |
